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Funding

  • NIH R01 (2018-2023)
  • NSF CAREER, BRIGE etc. (2009-2019)
  • Edgerton Innovation Award, UNL College of Engineering (2013)
  • US Army Research Office (ARO, 2009-2012)
  • NASA Nebraska Space Grant (2009-2012)
  • SD Board of Regents Competitive Research Grant (2008)

Fibrotic tissue stretch as an index for lumen gain

To develop in silico experiments and physical measurements for elucidating issues in stent deployment in highly calcified lesions and establishing guidelines for treatment

To apply machine learning methods for quantifying calcification

Enhance your PCI decision-making—use our app to identify when plaque modification is recommended. App Link

DOI: https://doi.org/10.1016/j.jmbbm.2021.104609

graphs illustrating research of fibrotic tissue stretch as an index for lumen gain and our app that helps to identify when plaque modification is recommended in PCI

Stent Mechanotransduction: role of solid mechanics & hemodynamics

To understand the mechanism of in-stent restenosis from multiple scales (cell, tissue, organ) and multiphysics ( blood-artery interactions).

Traumatic injury due to Blast or Impact 

To characterize the blast or impact induced brain damage and optic nerve damage

To develop mechanical measures using integrated experimental and computational approaches.  

To identify the role of protective gears  

Image assisted analysis

To transform 2D images data, such as CT , MRI or microscopy, to 3D solid model with the utmost accuracy and flexibility, and perform a variety of design and analysis on the 3D model.

Multiscle Material Chracterization 

To characterize the mechanical properties of the native & engineered tissue including cells and fibers, and identify the threshold of tissue/cell injuries

Quantification of fiber networks

To optimize the microenvironment of cells and design future clinical relevant biomaterials.

Nanocomposites

To design and optimize the composition of nanocomposite for a targeted performance/function.

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