Near-Infrared Spectroscopy (NIRS) System for Brain Monitoring
Sponsor: NASA Florida Space Grant

Concussive injury is believed to be vastly underreported and undertreated. Cerebrovascular mechanisms are often dysfunctional following concussion, and this condition is believed to cause at least some long term postconcussive symptoms. Incomplete normalization of physiological injury is thought to play an important role in increased vulnerability to subsequent trauma. Cerebrovascular control mechanisms in healthy people act by dilating or constricting cerebral blood vessels to regulate cerebral blood flow (CBF). Direct measurements of CBF are not practical, and surrogate parameters are substituted in current clinical protocols for cerebrovascular assessments. This project will explore the use of noninvasive cerebral bioimpedance and regional oxygen saturation (rSO2) for assessment of CBF changes for a simple and inexpensive approach to objective evaluation of concussion.

Publications:

Prasad, R., Seshadri, N.P., Periyasamy, R., Miller, S., Bit, A., and Mitra, K., “EEG and NIRS Based Hybrid Biomarker for Brain Imaging,” Bioelectronics and Medical Devices, Chapter 9, edited by Pal et al., Elsevier (January, 2019).

Miller, S., and, Mitra, K., “NIRS-Based Cerbrovascular Regulation Assessment: Exercise and Cerebrovascular Reactivity,” SPIE Neurophotonics, Vol 4(4), 041503 (2017), doi: 10.1117/1.NPh.4.4.041503.

Miller, S., Richmond, I., Borgos, J., and, Mitra, K., “NIRS-based Noninvasive Cerbrovascular Regulation Assessment,” SPIE Photonics West BIOS- Optical Interactions with Tissues and Cells, San Francisco (California), Paper No. 9706-60, February 13-18 (2016).

Miller, S., Richmond, I., Borgos, J., and, Mitra, K., “Development of Non-Invasive Method for Cerbrovascular Regulation Assessment,” Biomedical Engineering Society Annual Meeting, Tampa (Florida), Paper No. BMES 2015:2010, October 7-10 (2015).