Kishore Lab - Functional Biomaterials and Tissue Engineering
Welcome to Kishore Lab
Research in Dr. Kishore's Functional Biomaterials and Tissue Engineering Laboratory focuses on recreating the tissue extracellular microenvironment by employing novel scaffold fabrication methods and studying the role of ECM physicochemical properties on cellular differentiation and matrix remodeling. Specific projects include reconstruction of injured bone-tendon/bone-ligament interfaces, replacement of diseased small-diameter arteries, and development of in vitro biomimetic tissue models for the investigation of neurological disorders. For each of the projects, different fabrication methods (e.g., 3D bioprinting, electrochemical compaction) are employed to develop scaffolds that mimic the composition, mechanical properties, and structure of native tissue. Studies focus on elucidating cell-biomaterial interactions in vitro, scale-up of the biofabrication process for automated and large scale production of bioscaffolds, and investigating the in vivo performance of the bioscaffolds towards clinical translation. Research in Kishore lab has been supported by funding from the NIH. Results from this work have been published in high-tier journals that include Biomaterials, Acta Biomaterialia, Biofabrication, Journal of Biomedical Materials Research and Biomedical Materials.