Kishore Lab - Functional Biomaterials and Tissue Engineering
Welcome to Kishore Lab
Research in Dr. Kishore's Functional Biomaterials and Tissue Engineering Laboratory focuses on recreating the tissue extracellular microenvironment by employing novel scaffold fabrication methods and studying the role of different ECM-based biophysical and biochemical properties on tissue-specific cell differentiation and matrix remodeling. Specific projects include developing biomimetic gradient scaffolds for the reconstruction of injured bone-tendon/bone-ligament interfaces, investigating the effects of blue light-mediated photobiomodulation strategies on osteogenesis for use in bone and periodontal tissue engineering, and development of in vitro biomimetic tissue models for the investigation of neurological disorders. For each of the projects, different fabrication methods (3D/4D printing, electrochemical compaction) are employed to develop scaffolds that mimic the composition, mechanical properties, and structure of native tissue. Studies focus on elucidating cell-biomaterial interactions in vitro and investigating the in vivo performance of the bioscaffolds towards clinical translation. Research in Kishore lab has been supported by continued funding from the NIH. Results from this work have been published in high-tier journals that include Biomaterials, Acta Biomaterialia, Biofabrication, Biomacromolecules, Journal of Biomedical Materials Research and Biomedical Materials.
