The ability to respond to external stimuli, biotic or abiotic, is a fundamental characteristic of living orgnaisms. While many of these are visual, mechanical, or auditory cues, a large subset of them are in fact chemical. In humans, these chemical cues are typically detected/processed by the senses of taste and smell. Across the Kingdoms of Life, chemical cues regulate a rich assortment of inter- and intra- organismal behaviors which can significantly impact their chances for survival. The synthesis, release, environmental modification/degradation, perception, and response to these molecules are all rich areas for research. Understanding how these molecules 'work' depend on understanding these factors collectively, a multi-discipline problem. The Palmer Lab of Chemical Ecology works at the interface of the disciplines of Chemistry and Biology to resolve issues of small molecule signaling/regulation.